RAF Typhoon FGR4s have operated alongside French warplanes in a combined operation on an hidden munitions depot in Syrian territory employed by the IS group, according to the British defence ministry.
The site, identified by intelligence, was thought to be containing munitions and bombs, the release indicated, and was situated in hills just to the north of the ancient city of Palmyra in Syria's central region.
"The RAF jets utilized laser-guided Paveway IV weapons to strike a number of entry passages leading to the facility... initial indications indicate the objective was successfully hit," the MoD said.
There was no indication of any civilian casualties in the strike conducted Saturday night and each participating jet made a safe return, the defence officials confirmed.
The British jets were backed up by a Voyager refuelling tanker.
The Islamic State group - referred to as Daesh - enforced militant control over large swathes of both Syria and Iraq prior to its 2019 collapse.
"This strike underscores the UK's leading role, and commitment to work closely with our allies, to eradicate any re-emergence of Daesh and their violent and radical beliefs in the region," UK Defence Secretary the Defence Secretary said.
RAF aircraft have performed overwatch operations over Syria to "forestall any efforts to regroup" of IS subsequent to its routing at the battle of Baghuz in the year 2019, the MoD reported.
"I want to thank the personnel of the UK armed forces who took part in this strike for their professionalism and their bravery," the Defence Secretary commented. "They were among a great many UK service members stationed over the holidays. This operation, to eliminate militants who threaten our security, shows how UK forces are always on standby, continuously, keeping Britain secure domestically and influential overseas."
Last December, the United States armed forces executed what it called a "massive strike" targeting IS targets in the country, following an ambush claimed the lives of two American soldiers and a local interpreter in the Palmyra area.
The United Nations reports IS still boasts roughly 5-7 thousand combatants in both countries.
